p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice
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چکیده
منابع مشابه
p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.
Cisplatin is an important chemotherapeutic agent but can cause acute renal injury. Part of this acute renal injury is mediated through tumor necrosis factor-alpha (TNF-alpha). The pathway through which cisplatin mediates the production of TNF-alpha and injury is not known. Cisplatin activates p38 MAPK and induces apoptosis in cancer cells. p38 MAPK activation leads to increased production of TN...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2005
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00401.2004